A new age in digital transformation is requiring manufacturers to rethink their existing business models and corresponding infrastructure. To remain relevant and competitive in the age of Industry 4.0, manufacturers need to do more than simply adopt digital technologies and deploy predefined processes in isolated islands of automation as they have done in the past. The future of industry rests on understanding what is driving this new wave of digitization, how our current model of industrial automation is changing, and embracing what the future holds.